Platform Pillars
Proprietary Human Assay Systems
- PBMC inflammasome assay -- validated readouts of IL-1β and other inflammatory biomarker secretion
- HTS system -- miniaturized assay system, reduced noise, and high-throughput screening enablement
- Novel model development -- PPi biology for CPPD-relevant disease-modifying pathways
Multi-Omics Discovery & Drug Response
- Genetics -- large gout and CPPD datasets to identify novel regulatory pathways and causal nodes
- Proteomics & Transcriptomics -- molecular profiling of inflammasome responses
- Metabolomics -- metabolic signatures of disease
What Sets Us Apart
Human, Not Rodent-Forward
Discovery begins in human immune cells -- not animal models back-translated to patients.
Genetics-Informed Targets
Target nomination powered by large-scale human genetics.
Flare-Specific, Not Generic
Modulators of inflammasome regulation and downstream effector programs -- not generic immunosuppression.
Partnered Services
Mechanistic De-risking & MoA
- Test assets in human flare biology
- Define pathways, on-target/off-target inflammatory signatures
- Generate translation-ready readouts mapping to clinical endpoints
Biomarker Discovery
- Multi-omics (proteomics, transcriptomics, metabolomics +/- genetics)
- Cross-validation in our PBMC system
Responder Stratification
- Use multi-omics to identify responder/non-responder
- Detect immune risk patterns and adverse-response predictors
- Tighten inclusion criteria and reduce trial noise
Engagement Model
Scoping
Align on your crystal disease questions, define sample and assay requirements, and agree on deliverables tied to your program milestones.
Study Design
Select from human flare assays and omics modalities matched to your endpoints, with a defined integration plan, timeline, and go/no-go criteria.
Execution & Analysis
Assay runs in validated human systems, multi-omics data generation, and integrated analysis to generate mechanistic insights specific to your compound or target.
Deliverables
Actionable biology: pathway signatures, biomarker candidates, and translational recommendations mapped to your next decision point.
Start a conversation about your program
Reach out to discuss how our platform can support your research.